Intracellular site of insulin action: mitochondrial Krebs cycle.
نویسندگان
چکیده
Effect of insulin on the oxidation of carbons-1,4 and -2,3 of succinate and their incorporation into protein were studied in isolated rat hepatocytes and diaphragm muscle pieces. Oxidation of carbons-2,3 of succinate and their incorporation into hepatocyte protein were stimulated significantly by insulin. Insulin had only a trivial effect on 14CO2 formation from the carboxyl carbons of succinate. These data suggest that insulin affects only those carbons of succinate that are metabolized in the intramitochondrial Krebs cycle.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 83 14 شماره
صفحات -
تاریخ انتشار 1986